Thin-thickness versus blade-thickness micro-skin pulping covered with heterogeneous skin for repair of burn wounds

doi:10.3969/j.issn.2095-4344.2014.46.008

Abstract

Abstract:

BACKGROUND: Autologous micro-skin graft covered with allogeneic skin has become a major means for repair of extremely severe burn wounds. Due to the limitation of the source of allogeneic skin, heterogeneous skin (pigskin) or artificial skin serves as a vector to cover the wound on the clinical use.

OBJECTIVE: To observe the curative effect of thin-thickness micro-skin pulping covered with heterogeneous skin for repair of burn wounds in comparison with blade-thickness micro-skin pulping covered with heterogeneous skin.

METHODS: A self-control study was performed in 36 patients with severe burns of bilateral limbs. There were 42 pairs of wounds, 32 of which were at joint sites. One or two pairs of III-degree burns treated with escharectomy were selected from each patient for self-control comparison. Covered with heterogeneous skin, thin-thickness micro-skin pulping and blade-thickness micro-skin pulping were used in the trial and control groups, respectively. The expansion ratio was controlled at 1:8-1:12 in all patients. Wound healing time, degree of scar hyperplasia within 6 months to 2 years after transplantation, and ratio of reconstruction surgery at joint sites were observed and compared. The removed scars by surgery were analyzed based on the total score of the Vancouver Scar Scale.

RESULTS AND CONCLUSION: The average wound healing time was (44.7±1.24) days in the trial group and (49.6±1.41) days in the control group, and there was a significant difference between the two groups (P < 0.05). The trial group exhibited less scar hyperplasia than the control group at 6 months to 2 years after transplantation. Compared with the control group, the ratio of severe scar hyperplasia was significantly less in the trial group (P < 0.05), while the ratio of mild scar hyperplasia was obviously greater in the trial group (P < 0.01). However, there was no difference in the ratio of moderate scar hyperplasia between the two groups (P > 0.05). The reconstructive surgery ratio of the trial group was 38%, significantly lower than that of the control group (59.38%; P < 0.01). The total score on the Vancouver Scar Scale was less in the trial group than the control group (P < 0.05). These findings suggest that the thin-thickness micro-skin covered with heterogeneous skin is likely to be a better treatment to repair large full-thickness skin burn by increasing the thickness of micro-skin, and it can obtain better wound healing quality.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: skin transplantation, transplantation, heterologous, burns, cicatrix

CLC Number:

R318

Zhang Ming-zhu, Wang Jian-hua, Li Hu, Dong Yun-feng, Qi Chang-chun, Guo Bao-wen, Wang Yong-ling, Liu Xiao-yan, Li Yun-feng, Zhang Xiao-hui, Liu Ying, Li Xing-hua, Wang Hong-feng, Yu Qiang. Thin-thickness versus blade-thickness micro-skin pulping covered with heterogeneous skin for repair of burn wounds [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(46): 7417-7421.

Figures/Tables 1

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